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INNOVATIVE PHARMACEUTICAL FORMS

ACADEMIC YEAR2019/2020

COD. 16727

dati insegnamento:

DEGREE: PHARMACY

TYPE OF COURSE: COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

LECTURERS:

NICOLI Sara

ACADEMIC YEAR: 2019/2020

YEAR OF STUDY: 4

SEMESTER: First semester

NUMBER OF CREDITS: 5

UNIT COORDINATOR: NICOLI Sara

CONTACT HOURS: 40

INDIVIDUAL WORK HOURS: 75

Course contents

The first lecture of the course presents the rationale of the innovative pharmaceutical formulations and highlight the background needed to deal with this course. The program is the following:
General topics
• INTRODUCTION: INNOVATIVE PHARMACEUTICAL FORMULATIONS AND CONTROLLED RELEASE
• BIOAVAILABILITY – ABSORPTION
• POLYMERS FOR CONTROLLED DRUG DELIVERY
• DIFFUSIONE AND DISSOLUTION
Innovative formulations
• RESERVOIR. Behavior, drug release kinetic, advantages, limitations, examples of products on the market
• MATRICES. Inert, erodible, swellable matrices. Behavior, drug release kinetic, advantages, limitations, examples of products on the market
• OSMOTIC SYSTEMS Behavior, drug release kinetic, advantages, limitations, examples of products on the market
• GASTRORETENTIVE SYSTEMS Behavior, drug release kinetic, advantages, limitations, examples of products on the market
• COLON DELIVERY Behavior, drug release kinetic, advantages, limitations, examples of products on the market
• MUCOADHESION and MUCUS-PENETRATION. Structure of mucus and characteristics of mucoadhesive and mucus-penetrating polymers. Theories for mucoadhesion. Examples of mucoadhesive formulations for different administration routes.
• MICROPARTICLES. Preparation methods and applications
• NANOPARTICLES Preparation and characterization methods. Applications
• LIPOSOMES Preparation and characterization methods. Applications

• HYDROGELS. Properties, stimuli responsive hydrogels, examples
Alternative administration routes
• TRANSDERMAL DRUG DELIVERY. Advantages and limitations. Transdermal patches: preparation, characterization and marketed products
• NASAL AND PULMONARY DRUG DELIVERY. Advantages and limitations. Examples of formulations
• BUCCAL DRUG DELIVERY. Advantages and limitations. Examples of buccal formulations
• ORAL ADMINISTRATION OF PEPTIDE AND PROTEINS Problems and possible solutions: particulate systems, enzyme inhibitors, absorption enhancers
• OCULAR DRUG DELIVERY (local action). Administration problems in the treatment of anterior and posterior segment eye diseases. Innovative formulations

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INNOVATIVE PHARMACEUTICAL FORMS

Course contents

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YEAR: 4

YEAR: 5