PHARMACEUTICAL AND TOXICOLOGICAL CHEMISTRY II
Learning outcomes of the course unit
At the end of the teaching activity, the student must have acquired chemistry knowledge of the classes of drugs treated in the program and the most important concepts in medicinal chemistry. In particular, the student should be able to:
-Understand the chemical characteristics of the drugs included in the therapeutic classes treated in the program, their uses, the biological activity and toxicity, the relationship between the chemical structure and biological activity, the mechanism of action, the chemical-physical and metabolic aspects (Knowledge and understanding).
-Be able to interpret the pharmacological profile of drugs and metabolic and toxicological characteristics; apply the acquired knowledge to the discussion of the structure of the activity; identify the structural characteristics of drugs that are important for their action; be able to use a correct nomenclature according to international rules (Ability to apply knowledge and understanding).
-Expose concepts in a clear and straightforward way and through a formally correct and proper language, be able to interact with people with scientific training in different areas. (Communication Skills).
- Draw consequences on the use of drugs based on their structural, chemical and physicochemical properties (Making judgements).
Basic knowledge of medicinal chemistry, biochemistry, organic chemistry, physiology and pharmacology. In particular, knowledge of the functional groups of organic chemistry and of the heterocyclic rings, the main metabolic reactions, basic concepts of pharmacolog and physiology.
Course contents summary
Pharmaceutical and Toxicological Chemistry II integrates with the Pharmaceutical and Toxicological Chemistry II and Supplement to Pharmaceutical Chemistry courses for the treatment of the main classes of drugs.
The course deals with drugs with activity on the central and peripheral nervous system and on the cardiovascular system. For each class are described the chemical structures of the main drugs, the mechanisms of action and structure-activity relationships, the chemical and physical-physical properties, the metabolism, the toxicity and the therapeutic applications.
Drugs acting on the nervous system. Principal neurotransmitters of the Nervous System. -Depressors of the Nervous System: General anesthetics: intravenously and by inhalation. Hypno-sedatives. Analgesic narcotic: natural prototypes, derived synthesis and semi-synthesis. Anticonvulsants. Antiparkinson. Muscle relaxants. Anxiolytics. Neuroleptics. Local anesthetics. -Nervous System Stimulants: central analeptic. Psychostimulants. Antidepressants. Hallucinogens. Drugs of the sympathetic nervous system and parasympathetic nervous system. Cardiovascular Drugs: Drugs heart: cardiac glycosides, antiarhythmics and antianginal. ACE inhibitors, calcium channel blockers. Diuretics. Antacids and inhibitors of gastric acid secretion.
Thomas L. Lemke, David A. Williams, Victoria F. Roche, S. William Zito: Foye's Principi di Chimica Farmaceutica, Piccin.
G.L. PATRICK: "Introduzione alla Chimica Farmaceutica", EdiSES.
WILSON & GISVOLD: "Chimica Farmaceutica", casa Editrice Ambrosiana.
Alberto Gasco, Fulvio Gualtieri, Carlo Melchiorre: Chimica Farmaceutica; Casa Editrice Ambrosiana, Milano.
Through oral lessons will be presented and discussed matters relating to the course content. Lectures are conducted with the aid of slides. The slides used to support the lessons will be loaded before the lesson on the Elly platform. Registration for the course is required to download the slides. The teaching material available online is not a replacement but a supplementary of reference texts, and a guide to a better understanding of the topics to be studied.
Assessment methods and criteria
The assessment of the achievement of the course's objectives is done through oral examination. The exam focuses on two topics.
For the determination of the profit, expressed in thirtieths, the following criteria are adopted:
- acquired knowledge and understanding of the topics covered (18/30);
- ability to apply knowledge acquired with method mastery (up to 9/30); the student must be able to connect the different parts of the teaching, to interpret the pharmacological profile of the drugs, to discuss the relationships between the structure and the biological activity and the pharmacokinetic properties.
- ability to communicate knowledge and skills in a verbal form through the correct use of a specific language of the discipline (up to 3/30).
The results are reported immediately and then published on the ESSE3 portal.