Learning outcomes of the course unit
Once completed the course and acquired the corresponding CFU, the student will be able:
- to understand causes and mechanisms underlying the main pathologic processes at cell levels, together the main consequences at tissue and organism level
- to apply this knowledge to biotechnological approaches aimed at the therapy of relevant human pathologies
- to analyze and describe, exhibiting a critical approach and exploiting the bibliographic sources provided, a pathological process enlisted in the detailed program
Bases of Molecular Biology, Biochemistry, and Cell Biology are required.
The acquisition of CFU on these subjects is strongly recommended for a fruitful frequence to the Course.
The teacher will perform short diagnostic evaluations before every main session of lectures so as to provide, if needed, recommendation for proper reharsal.
Course contents summary
Lectures will concern three main subjects:
- Cell pathology: injury, adaptation, death
- Molecular and genetic pathology
1) Cell pathology
- Types and mechanisms of cell injury
- Cell stress and cell response to stress: oxidative, ER stress, ischemic-hypoxic
- Intracellular and extracellular accumulations
- Cell death: accidental, regulated, programmed
- Modalities of cell death;: necrosis, apoptosis, other modalities
- Tissue adaptations: atrophy, hypertrophy, hyperplasia, metaplasia, dysplasia
- Aging: from cells to organisms
2) Molecular and genetic disease
- Mutations and their phenotypic effects
- Repair of DNA damage
- Mendelian disorders with pertinent examples: autosomic dominant (familial hypercholesterolemia, Marfan syndrome, neurofibromatosis); autosomic recessive (aminoacidopathies and hyperphenylalaninemias; cystic fibrosis); X-linked (hemophilia, muscle dystrophies)
- Non-mendelian disorders (mitochondrial diseases, genomic imprinting, triplet expansion, multifactorial diseases)
- Chromosomal aberrations
- Nomenclature and classification
- Benign and malignant tumors
- Molecular oncology: the molecular control of the cell cycle and death, protooncogenes and oncosuppressors, the genetic control of DNA repair
- Causes of tumours: chemical, physical, biological
- The neoplastic phenotype: invasivity, metastasis, progression angiogenesis, metabolic alterations
- Kumar, Abbas, Fausto, Aster- Robbins e Cotran – Le basi patologiche
delle malattie, 8 ed. Elsevier-Masson
- Parola Patologia Generale
Specific bibliographic references will be provided during the lessons
Oral interactive lessons, supported by slides that will be made available to the students on Elly platform at the beginning of the course (with possible up-dates at the end of the lectures).
Lessons will present the main conceptual frame of each subject, summoning questions or doubts from the audience and indicating bibliographic references for in-depth study of the subject.
Slides are to be considered an essential, yet NOT exhaustive, didactic resource.
Students who cannot attend the lectures are warmly invited to check regularly the Elly Platform for didactic material and communications.
Assessment methods and criteria
No interim summative evaluation is scheduled.
However, interim diagnostic or formative evaluations will be possible.
The final evaluation will consist in an oral examination.
Q u e s t i o n s / s t u d e n t : 2 (from two d i f f e r e n t e x a m i n e r s , o n e
q u e s t i o n / e x a m i n e r; one question will be on a subject chosen by the student).
Questions will consist in the headings listed in the detailed program.
No answer to one question, or the verified uncapability to define
correctly the subject of the question, will prevent the successful completion of the exam.
After each question, the examiner will give an evalaution expressed in marks (30/30):
A. Very good knowledge and understanding. Very good capability of
applying knowledge to bio-medical problems. Corresponding to 30/30.
B. Good knowledge and understanding. Good capability to apply
knowledge to biomedical problems. Corresponding to 27-29/30.
C. Average knowledge and understanding. Average capability of
applying knowledge to bio-medical problems. Corresponding to 24-26/30.
D. Sufficient knowledge and understanding. Sufficient capability of
applying information to bio-medical problems. Corresponding to 21-
2 3 / 3 0 .
E. Barely sufficient knowledge and understanding (with evident pitfalls).
Scarce capability of applying knowledge to bio-medical problems.
Corresponding to 18-20/30.
Full marks with laude will be reserved to students exhibiting, together an
overal evaluation of 30/30, capability of making judgments and good
communication ability and autonomous learning skills.
The final vote will be decided jointly by the examiners, who will have the
possibility to decide a vote not higher or lower than three grades from
the best or the worst vote derived from the mean of the two individual