Learning outcomes of the course unit
The objectives of course are to enable the acquisition of knowledge and
understanding the mechanism of proliferation and cell death, the
mechanism of response to injury (inflammation, hemostasis, tissue
repair), the pathogenesis of some human genetic diseases, the biological
characteristics of the tumors, as well as the essential mechanisms of the
immune response and its alterations, with particular reference to
applications in transfusional medicine and to the aspects of interest in
The course allows the student to apply the knowledge and understanding
gained in the professional future.
Sufficient knowledge of biology, anatomy, biochemistry and physiology
are needed to address the topics of the course.
Course contents summary
General alteration of growth and death, cellular and molecular oncology,
genetic and metabolic diseases and general physiopathology. Blood and
hematopoiesis and components of innate and acquired immune system.
General features of acute and chronic inflammation and
immunopathology. Immunoemathology and transfusional medicine.
Cellular Pathology: Cellular alterations of growth and differentiation.
Hyperplasia, hypertrophy, atrophy, metaplasia, dysplasia. Necrosis and
Oncology: classification and nomenclature; Benignant and malignant
tumors; Tumor aetiology; Fundamentals in molecular oncology; invasivity
and metastasis; pathogenesis of neoplastic diseases. Grading and
The blood: composition, cells, general pathophysiology. Anemia and
Thalassemia syndromes. Leukemia and lymphoma. Phases and event of
the haemostatic response. Hemorrhagic disorders; thrombosis and
Inflammation: events of acute inflammation; the exudate; types of
exudate; phagocytosis; chronic inflammation and granulomas; abscesses
and ulcers; chemical mediators of inflammation; systemic effects of
inflammation and fever; tissue repair.
Genetic disorders: mutations; monogenic diseases: examples of
autosomic dominant, autosomic recessive and X-linked disorders;
Multifactorial disorders: atherosclerosis, diabetes mellitus.
Innate and adaptive immunity: distinction and cooperation. Antigens and
Antibodies. Ag-Ab interaction. Lymphocyte receptors.
The Major Histocompatibility Complex (MHC). Functional anatomy of the immune
response. Lymphocyte activation and effector functions. Primary and
secondary reaction. Principles of vaccination. Immune response to
infections. Hypersensitivity. Primary and secondary immunodeficencies.
Blood groups. AB0 system. Rh system. Other blood groups. Hemolytic
disease of the newborn. Fundamentals of transfusional practice.
- J. Maier e Mariotti “Elementi di Patologia Generale e Fisiopatologia”
- V. Del Gobbo "Immunologia per le lauree sanitarie" III ed., Piccin
- G.M. Pontieri “Elementi di Patologia Generale per i Corsi di Laurea in
Professioni Sanitarie” III ed., Piccin
- G.M. Pontieri “Elementi di Fisiopatologia Generale per i Corsi di Laurea
in Professioni Sanitarie” III ed., Piccin
The topics in the program will be presented and discussed through
lectures trying to involve the student so that it can be an active part of
Assessment methods and criteria
Learning outcomes will be verified through an oral examination.
Questions on the topics relating to the course will be used to test
knowledge and understanding of the student in the scientific discipline,
and her/his ability to apply such knowledge and understanding in