The student, taking also in account the knowledge of anatomy, biology, physiology, general pathology and biochemistry already acquired in previous Courses, should demonstrate understanding about:
the chemistry of radioactive molecules,
the major pharmaceutical forms and routes of administration of radiopharmaceuticals
the distribution of radioactive molecules in the body,
the prototype molecules used in radiodiagnostic and radiotherapy,
the toxic effects of radionuclides on the body and how to avoid them.
The student, even collaborating with other professionals, should be able to:
contribute to the preparation of radiopharmaceuticals for administration and for programs related to it,
identify the problems related to radioactive drug therapy,
provide adequate support to the subject undergoing treatment.
Having passed the basic teachings (biochemistry, anatomy, physiology, radiology).
Course contents summary
Knowledge of radiopharmaceuticals and their use
Synthesis and preparation of labeled compounds; quality control of radiopharmaceuticals: stability and purity; rules of good laboratory practice.
Structure and characteristics of radioactive drugs, nomenclature.
General principles of pharmacokinetics and pharmacodynamics of radiopharmaceuticals: Pharmaceutical forms and routes of administration of radionuclides.
Concept of bioavailability.
Correct timing and protocols of radionuclide administration.
Characteristics and indications for use of radionuclides.
Organ-specific compounds: Iodine and iodinated radionuclides, rubidium, fluorine and derivatives, Technetium. Radionuclides designed for Central nervous system: markers of the aminergic systems.
Radionuclides and molecules designed for renal and pulmonary scintigraphy.
Radionuclides designed for cardiac scintigraphy
Metabolic therapy and radiotherapy.
Legal and liability issues.
Specific text are not available. The course material (slides in ppt format) will be made available by the teacher at the end of the course.