COSMETIC PRODUCTS - INNOVATIVE DRUG DELIVERY SYSTEMS
Learning outcomes of the course unit
At the end of the course the student should have acquired knowledge and understanding of functional cosmetic, of cosmetic technology both traditional and innovative and of cosmetic legislation.
In particular, the student should:
1. Be able to understand the functional mechanisms of the skin. Know functional cosmetic and cosmetic technology. Be able to use the specific language and the correct terminology for cosmetic ingredients. Know the European Regulatory Guidelines for Cosmetics with regards to fabrication, import and commercialization of cosmetics products (knowledge and understanding).
2. Be able to recognize the function of each excipient of a given cosmetic product and the possible interactions among them. Be capable of formulating the main categories of cosmetic products (solutions, creams, lotions, detergents) (applying knowledge and understanding).
3. Be able to communicate the results of scientific studies also to a non-expert audience. Be able to write a formal document, neat, understandable and appropriate for the professional context. Be able to produce a written document morphologically, syntactically and grammatically correct (communication skills).
4. Be able to evaluate the quality of a cosmetic product as a function of its composition and the instruction for use indicated (making judgements).
Be able to connect the different subject studied among them and with the basic disciplines. Have the capability of continuous education, through the scientific publications in the field of pharmaceutical technology (learning skills).
The purpose of this course is to acquire a deep-rooted knowledge of the fundamental principles of the controlled drug delivery and innovative formulations (both marketed and in-development) and to develop the ability to apply these principles to different kind of formulations and administration route. A further aim of the course is to provide the students the tools for the elaboration of the information given so as to integrate them into their knowledge. In particular at the end of the course the student shall:
-have aquired specific knowledge on mechanisms, materials, processes and formulations
-be able to compare the innovative formulations with the traditional ones
-be able to highlight, for every innovative formulation/administration route, potentialities, limits and impact on patient therapy
-be able to present (orally or in writing) the topics studied in a clear way and using a correct technical language
Pharmaceutical technology is a pre-requisite.
Course contents summary
The contents of module 1 are:
• Anatomy, physiology and biochemistry of the skin and its annexes.
• Factors affecting skin permeation and retention of cosmetic ingredients.
• European Regulatory Guidelines for fabrication, import and commercialization of cosmetics products (1223/2009/CE).
• Cosmetic raw materials: inactive components.
• Traditional cosmetic formulations: solutions, suspensions, emulsions, gels, solid mixtures, pressurized formulations.
• Innovative cosmetic formulations: liposomes, nanoparticles, liquid crystals.
• Detergents: composition and characteristics.
• Skin types and cosmetic treatments.
• Antiaging strategies.
• Cosmetic applications of alpha-hydroxy-acids.
• Cosmetics for dental hygiene.
• Sun and skin: effect of solar radiation, sunscreens, self-bronzers.
• Hair cosmetics: shampoo, conditioners, gels, mousses, product for the change of hair shape, hair colors.
• Body cosmetics: cellulitis and stretch marks cosmetic treatments.
• Decorative cosmetics: foundations, eye shades, mascara, lip sticks, nail enamel.
• Cosmetic packaging.
• Evaluation of stability and efficacy of cosmetic products.
The contents of module 2 are:
The first lecture of the course presents the rationale of the innovative pharmaceutical formulations and highlight the background needed to deal with this course. The program is the following:
• INTRODUCTION: INNOVATIVE PHARMACEUTICAL FORMULATIONS AND CONTROLLED RELEASE
• BIOAVAILABILITY – ABSORPTION
• POLYMERS FOR CONTROLLED DRUG DELIVERY
• DIFFUSIONE AND DISSOLUTION
• OSMOTIC SYSTEMS
• GASTRORETENTIVE SYSTEMS
• COLON DELIVERY
Alternative administration routes
• TRANSDERMAL DRUG DELIVERY
• BUCCAL DRUG DELIVERY
• ORAL ADMINISTRATION OF PEPTIDE AND PROTEINS
• OCULAR DRUG DELIVERY
G. D’Agostinis e E. Mignini, Manuale del Cosmetologo, II Edizione, Ed. Tecniche Nuove (Milano) (in Italian)
Textbooks for consultation (available in the library of the Dipartimento di Scienze degli Alimenti e del Farmaco):
• G. Proserpio, Le basi della cosmetologia, Ed. SEPEM, Milano. (in Italian)
• I. Bonadeo, Prodotti Cosmetici, cosmetologia e tecnologia cosmetiche, Ed. Librería Cortina (Milano) (in Italian)
Textbook: Principi di tecnologie farmaceutiche, P. Colombo, P.L. Catellani, A. Gazzaniga, E. Menegatti, E. Vidale, Casa Editrice Ambrosiana Ed. 2004
Since some topics are not present in the book, specific texts (available at the library of the Department of Pharmacy) will be suggested.
The teachers make available, on a weekly basis, copies of the slides on Elly portal (http://elly.farmacia.unipr.it/) (in Italian)
The course includes lessons, using slide projections, that will be available online for students (elly.saf.unipr.it/2017). Slides are complementary didactic material.
The teacher will recall continuously to the use of the appropriate technical language, will use everyday life examples, will underline connections among different parts of the course and will promote active student participation. 4 hours will be dedicated to exercises and mock examinations.
Assessment methods and criteria
The summative evaluation of the knowledge acquired is made through a written exam, made of two partials relative to the two modules. The student should, then, after online enrollment:
a) pass a written exam during the official dates established by the Dipartimento di Scienze degli Alimenti e del Farmaco (Module of cosmetic products, weight 50% of the overall grade);
b) pass a written exam during the official dates established by the Dipartimento di Scienze degli Alimenti e del Farmaco (Module of innovative pharmaceutical formulations, weight 50% of the overall grade);
Each written exam, duration 1 hour, consists of 6 open answer questions (score for each question varies from 0 to 3) and 10 multiple choice questions (score for each question varies from 0 to 1). Up to 2 points will be given for the communication skills of the student.
The student should demonstrate to have understood, and to be able to apply, the fundamental concepts of each subject studied. In particular, the evaluation of each module, expressed in thirtieths, will be made on the basis of the following criteria:
1. knowledge and comprehension (theoretical and practical) capability of the subjects studied;
2. Ability to make judgements and to connect the different subject studied among them;
3. communication skills and appropriate use of the technical language;
4. ability to learn and to elaborate the subjects studied.
The results of the exam are published on the portal ESSE3 (https://unipr.esse3.cineca.it/Home.do) within one week of the date of the exam. Students can see the exam, by appointment with the teacher.
A fac-simile of the examen is avaiable to the students on the Elly portal.