PHARMACOLOGY AND PHARMACOTHERAPY
Learning outcomes of the course unit
The course of PHARMACOLOGY & PHARMACOTERAPY, as well as toxicology and pathology, provides the body of knowledge in biomedical field needed to face the problems concerning the development and the utilization of drugs.
Le lessons are aimed to promote knowledge and understanding of the essential concepts specific to general and special pharmacology with the purpose to enrich applying knowledge of the students which will be able to exert making judgements based on learning skills and communication skills on both the experimental development of a new drug and the protocols of clinical practice.
Course contents summary
A first series of lessons deals with general topics such as drug invention, pharmacodynamics and pharmacokynetics (with relative parameters), unwanted effects and drug toxicity (indices of safety), individual variation and drug interaction, design and optimization of dosage regimens, elements of clinical pharmacology.
The second part of the course is devoted to the study of various classes of drugs affecting peripheral and central neurotransmission and therapeutics concerning current treatment of cardiovascular, gastroenterological, respiratory, endocrinological, central, inflammatory, microbial and neoplastic diseases
- Pharmacodynamics: drug targets, qualitative and quantitative aspects of drug-- target interactions;
- Pharmacokinetics: determinants of plasma drug concentrations and pharmacokinetic parameters
- Sources of variability in individual response to drugs
- Side effects of drugs and safety in therapeutics
- Development of new drugs and clinical trials
- Drugs acting on the autonomic nervous system
- Drugs acting on Neuromuscular Junction
- Drugs affecting the Central Nervous System
- Drugs affecting Gastrointestinal Tract
- Drugs affecting renal and cardiovascular system
- Drugs affecting the Respiratory System
- Pharmacological control of Hemostasis
- Pharmacological control of inflammatory and immune response
- Pharmacology of the Endocrine System
- Antimicrobial and antineoplastic chemotherapy
ANNUNZIATO & DI RENZO “Trattato di Farmacologia”. Idelson-Gnocchi, Napoli
KATZUNG BG. “Farmacologia Generale e Clinica”. Piccin, Padova
RANG HP et al. “Farmacologia” . Casa Editrice Ambrosiana, Milano
GOODMAN & GILMAN’S. “Le basi farmacologiche della terapia”. Zanichelli Editore
The development of teaching is based on frontal lessons that discuss critically the problems related to experimental pharmacology and pharmacotherapy. To support this activity are made available in electronic copy, articles published in biomedical journals, institutional guidelines and position papers of scientific societies as tools to develop learning skills authoritative even alone.
Assessment methods and criteria
The assessment of the achievement of the objectives of the course will include an oral examination which will also evaluate the communication skills of the candidate. Through questions concerning the general part of the course will be determined whether the student has achieved the goal of knowledge and understanding of the basic concepts of pharmacology. Through questions regarding pharmacotherapy will be determined whether the student has achieved the aim of applying the acquired knowledge to the problems inherent in everyday clinical practice by demonstrating ability to learn and to formulate independent judgments.