PERIOPERATIVE MEDICINE 1

Contents of the Course of Applied Pharmacology
• General information on drugs. Nomenclature, pharmaceutical forms, discovery and development of new drugs, drug prescription. Pharmacosurveillance.
• General principles of pharmacokinetics. Absorption, distribution, metabolism and elimination of drugs. Accumulation of drugs into the body.
• Routes of administration of drugs
• Bioavailability and Bioequivalence.
• Dosage of drugs and Therapeutic Regimens
• Principles of Pharmacodynamics: mechanism of drug action and molecular targets.
• Factors that modify the response to drugs
• Drug toxicity: intolerance and allergy. Idiosyncratic responses and principles of pharmacogenetics.
• Drug-drug interactions of clinical relevance.
• Drugs acting on the central nervous system. Benzodiazepines, antidepressants, adrenergic stimulants.
• Drugs for control of pain. Opioid analgesics. Local anesthetics. NSAIDs and acetaminophen.
• Competitive and depolarizing neuromuscular blockers. Botulinum toxin and direct antispasmodics.
• Steroidal anti-inflammatory drugs and immunosuppressants: focus on corticosteroids.
• Gastrointestinal drugs: antacids, histamine H2-receptor antagonists, proton pump inhibitors, antiemetics, prokinetics, anti-diarrhoics, laxatives.
• Cardiovascular drugs, antihypertensives, diuretics, antiarrhythmics, digitalis and other positive inotropes; coronaroactive drugs, drugs affecting hemostasis.
• Principles of chemotherapy and general information about major classes of antibacterial, antiviral and anticancer drugs