Learning outcomes of the course unit
The goal of the course is to provide the fundamental knowledge on the dosage forms, with particular emphasis on the role of the different components. The student will learn the nature and the classification of the excipients in order to be able to understand the role of the different their role in the different dosage forms and administration ways. At the end of the coarse the student should be able to understand and describe the various approaches for optimizing the therapeutic efficacy of an active ingredient.
Course contents summary
The course deals with the modern approach at the preparation of medicines, at the comprehension of the characteristics of the different dosage forms and of the peculiarity of some administration routes
• Drugs, dosage forms and medicines.
• Pharmacopoeia and Formulary
• Administration way and pharmacokinetics.
•Biopharmaceutical Classification System
• Unit Operation: Crystallisation, Distillation; Drying; Lyophilisation Sterilization; granulation.
• Pharmaceutical excipients.
• Dosage forms: powders; granules; capsules, tablets, suppositories drops, syrups: suspensions; emulsions; ointments; eyewash; injectables; aerosols; herbal remedies.
-Farmacopea Ufficiale della Repubblica Italiana, XII Edizione, Istituto Poligrafico e Zecca dello Stato, Roma (2015);
-P. Colombo, P.L. Catellani, A. Gazzaniga, E. Menegatti, E. Vidale Principi di Tecnologie Farmaceutiche, Casa Editrice Ambrosiana, Milano (2004)
-M. Amorosa, Principi di Tecnica Farmaceutica, Libreria Universitaria L. Tinarelli, Bologna (1998).
A.J. Winfield, R.M.E. Richards, Pharmaceutical Practice second edition, Churchill Livingstone London (1998);
A. Le Hir, Tecnica Farmaceutica, Edizione italiana a cura di G. Pifferi, Masson, Milano (1981).
The course will be carried out through frontal lessons during which the biopharmaceutical and pharmacokinetic aspects of the drug administration will be presented and discussed.
The most critical unit operations will be presented as well as the detailed description of the various classes of excipients and their role in the formulation.
Finally, to pursue the course goals the various dosage forms will be presented and discussed in agreement with the Pharmacopoeia classification.
Assessment methods and criteria
Oral exam with questions aiming at ascertain the knowledge, the comprehension capability and the competences acquired by the student. The results will be evaluated in 30th.
The whole evaluation will be the average of the notes obtained in the two modules.