LEARNING OUTCOMES OF THE COURSE UNIT
The course of Pharmacology is included in the integrated course of Medicine I.
The course aims to allow the student to know and to understand the principles that govern the interactions of drugs with the body, the principles of general toxicology, the adverse reactions of drugs and their evaluation, the fundamental aspects associated with the therapeutic use of some drugs of more specific interest, with potential ototoxic effects.
Applying the knowledge and the comprehension acquired, the student will be able to help to prevent complications from the use of drugs with potential ototoxic effects.
COURSE CONTENTS SUMMARY
The first part of the course concerns principles that govern the interactions of drugs with the body, both in terms of pharmacokinetics (absorption, metabolism, distribution and elimination) and pharmacodynamics (mechanism of action). The second part is addressed to discussion of the fundamental notions concerning the principles of general toxicology. The third part deals with the knowledge of the fundamental aspects associated with the therapeutic use of some drugs with potential ototoxic effects.
Rang H.P., Dale M.M., Ritter J.M., Flower R.J., Henderson G., FARMACOLOGIA. Milano: Elsevier, 2012. VII Italian edition
ASSESSMENT METHODS AND CRITERIA
It will be evaluated the knowledge and the understanding of the topics discussed in the course, taking into account the autonomy in making judgments, the communication skills and the learning skills of the student.
Class lessons: the program themes will be discussed with the aid of slides. The proposed topics will be the subject of collective discussion and study on the basis of ideas and any questions raised during the lessons themselves.
Introduction: general principles.
Pharmacokinetics: the dynamics of drug absorption, distribution, metabolism and elimination.
Pharmacodynamics. Molecular mechanisms of drug action. Relationship between drug concentration and effect. Relationship between drug dose and clinical response: factors that modify the drug response.
Toxicology: general principles, dose-response relationship, classification of undesirable effects.
Drugs with potential ototoxic effects.