Learning outcomes of the course unit
The objectives of the General Pathology course are to enable the acquisition of knowledge and understanding the mechanism of proliferation and cell death and their alteration in the biology of tumours, the pathogenesis of some human genetic and metabolic diseases with their related essential notions of semeiotic and medical terminology, the mechanism of innate and specific immune system, the pathogenesis of the main immunopathologic diseases, the ABO blood and the rhesus (Rh) blood groups, and problems related to blood transfusion.
Course contents summary
General alteration of growth and death, cellular and molecular and cellular oncology. Genetic and metabolic diseases and general physiopathology.
Blood and hematopoiesis and components of innate and acquired immune system. General features of acute and chronic inflammation and immunopathology. Immunoemathology and transfusional medicine.
Cellular Pathology and Physiopathology
Cellular alterations of growth and differentiation. Necrosis and apoptosis. Atrophy, hypertrophy, hyperplasia, metaplasia, dysplasia.
Definition, nomenclature, and biological properties of benign and malignant neoplasms. Molecular basis of cancer. Metastatic dissemination.
Blood and Hematopoiesis. Stem cells. Leukemia and lymphoma. Anemias. Transmission patterns of single-gene disorders. Examples of genetic disease. Chromosomal alterations.
Atherosclerosis, trombosis, angina and myocardial infarction.
General features of acute and chronic inflammation Vascular changes, cellular events and chemical mediators. Inflammatory exudate and systemic effects. Fever and hyperthermia. Chronic inflammation: classification, cytological features and granuloma. Tissue repair.
Diabetes mellitus and atherosclerosis.
Innate immunity. Acquired immunity. The structural and functional aspects of Antibodies. T and B lymphocytes and their receptors. The Major Histocompatibility System (MHC). Activation of B and T lymphocytes. Vaccinations. Hypersensitivity. Immunologic tolerance and pathogenesis of autoimmune diseases. Immunodeficiency
ABO blood groups and serum antibodies. The rhesus (Rh) blood groups. Other blood groups. Haemolytic disease of the newborn.
J. Maier e Mariotti “Elementi di Patologia Generale e Fisiopatologia” McGraw-Hill
- G.M. Pontieri “Elementi di Patologia Generale” III ed., Piccin
- V. Del Gobbo "Immunologia per le lauree sanitarie" III ed., Piccin
- A.K. Abbas e A.H. Lichtman "Le basi dell'immunologia" II ed., Masson
Parola M. “Patologia Generale” EDISES
The topics in the program will be presented and discussed through lectures trying to involve the student so that it can be an active part of the lesson.
Assessment methods and criteria
Learning outcomes will be verified through an oral examination. Questions on the topics relating to the course will be used to test knowledge and understanding of the student in the scientific discipline, and her/his ability to apply such knowledge and understanding in occupational contexts. Using the knowledge also acquired in other courses the student must demonstrate knowledge and understanding about the etio-pathogenetic mechanisms of human diseases with their related essential notions of semeiotic and medical terminology.