Learning outcomes of the course unit
Basic knowledge of the mechanisms underlying, tissue response to injury (inflammation, hemostasis, repair), genetic diseases, and tumors. Fundamentals of immune response and its alterations, with a peculiar emphasis on transfusion medicine and on subjects of particular relevance for obstetricians.
Basic elements of chemistry, biochemistry, anatomy and physiology.
Course contents summary
1. The blood: composition and pathophysiology. Anemia. 2. Inflammation:Events of acute inflammation; Exudate; Types of exudate; Phagocytosis; Chronic inflammation and granulomas; Abscesses and ulcers;
Chemical mediators of inflammation; Systemic effects of inflammation; Tissue repair. 3. Hemostasis:Phases and events of the hemostatic response; Hemorrhagic disorders; Thrombosis and embolism; Infarction. 4. Genetic disorders: Mutations; Single gene diseases; Examples ofautosomic dominant, autosomic recessive and X-linked disorders; Multifactorial disorders (malformations); Cytogenetic disorders. 5. The diabetic syndrome. Gestational diabetes. 6. Tumors: Classification and nomenclature; Benign and malignant tumors; Tumor etiology; Fundamentals in molecular oncology; Invasivity and metastasis; Pathogenesis of neoplastic diseases; Grading and staging. 7. Immunology: innate and adaptive immunity; Antigens and Antibodies. Ag-Ab interaction; Lymphocyte receptors; The Major Histocompatibility Complex (MHC) and Ag presentation; Functional anatomy of the immune response; Lymphocyte activation and effector functions; Primary and secondary reaction. Principles of vaccination. Immune response to infections. 8. Immunopathology: Hypersensitivity. Primary and secondary immunodeficencies. HIV infection. 9. Blood groups. AB0 system. Rh system. The hemolytic disease of the newborn.
Maier e Mariotti. Elementi di Patologia Generale e Fisiopatologia. McGrawHill.
Oral interactive lessons with iconographic support
Assessment methods and criteria