Learning outcomes of the course unit
The Course of Clinical Pathology is part of the Integrated Course of Perioperative Medicine.
The course aims to enable the student to know and understand the main laboratory tests, in order to achieve the ability to use the knowledge and understanding gained in identifying the patient's problems related to the disease.
knowledge of anatomy, physiology and general pathology
Course contents summary
The first lessons cover general topics regard to biological materials and preparation of the patient. The second part of the course covers the main laboratory tests and their clinical interpretation.
Contents of the Course of Applied Pharmacology
• General information on drugs. Nomenclature, pharmaceutical forms, discovery and development of new drugs, drug prescription. Pharmacosurveillance.
• General principles of pharmacokinetics. Absorption, distribution, metabolism and elimination of drugs. Accumulation of drugs into the body.
• Routes of administration of drugs
• Bioavailability and Bioequivalence.
• Dosage of drugs and Therapeutic Regimens
• Principles of Pharmacodynamics: mechanism of drug action and molecular targets.
• Factors that modify the response to drugs
• Drug toxicity: intolerance and allergy. Idiosyncratic responses and principles of pharmacogenetics.
• Drug-drug interactions of clinical relevance.
• Drugs acting on the central nervous system. Benzodiazepines, antidepressants, adrenergic stimulants.
• Drugs for control of pain. Opioid analgesics. Local anesthetics. NSAIDs and acetaminophen.
• Competitive and depolarizing neuromuscular blockers. Botulinum toxin and direct antispasmodics.
• Steroidal anti-inflammatory drugs and immunosuppressants: focus on corticosteroids.
• Gastrointestinal drugs: antacids, histamine H2-receptor antagonists, proton pump inhibitors, antiemetics, prokinetics, anti-diarrhoics, laxatives.
• Cardiovascular drugs, antihypertensives, diuretics, antiarrhythmics, digitalis and other positive inotropes; coronaroactive drugs, drugs affecting hemostasis.
• Principles of chemotherapy and general information about major classes of antibacterial, antiviral and anticancer drugs
G. Federici: Medicina di laboratorio – McGraw – Hill (last edition)
Frontal lessons. During the lessons will discuss the issues related to laboratory tests and their interpretation
Assessment methods and criteria
The assessment of the achievement of the objectives of the course will include in-course tests with multiple choice quiz. At the oral exam by questions regarding the contents of the course will be determined whether the student has achieved the goal of knowledge and understanding of the content and if it is able to apply the knowledge gained
Slides will be made available at the end of the course.