DRUG ANALYSIS I
Learning outcomes of the course unit
The course, composed by theoretical lessons and individual practice training, is aimed at providing the basic notions for the qualitative and quantitative determination of substances of pharmaceutical interest. In particular, during the practical training attention will be focused on the qualitative analysis and quantitative determination of inorganic compounds of pharmaceutical interest.
Basic knowledge of general and inorganic chemistry
Course contents summary
Safety and first aid procedures in the laboratory
Symbols, risk and safety phrases. Hazard chemicals handling procedures
Basic laboratory techniques and operations: solubilisation, dilution, precipitation, centrifugation, solvent extraction.
Solubility and solubility product
Lab equipment and instrumentation
Qualitative analysis in aqueous solution: identification of anions and cations.
Introduction to spectroscopic analysis
Lab equipment and instrumentation: the analytical balance, burettes, pipettes.
Experimental error: types of errors, precision and accuracy.
Standard and normal solutions
Choice of the indicator
Preparation and standardization of solutions
Alkalimetry and acidimetry
Complexometric and chelometric titrations
Analysis of the titration curve
Araneo A. “Chimica analitica qualitativa. Metodo periodale” Terza edizione, Casa Editrice Ambrosiana, Milano.
Harris D.C. “Chimica Analitica Quantitativa” Seconda edizione, Zanichelli, Bologna.
Abignente E., Melisi D., Rimoli M.G. "Principi di Analisi Quantitativa dei Medicinali" Seconda edizione, Loghia, Napoli.
Oral lessons and practical exercises in the laboratory
Assessment methods and criteria
Practical in itinere evaluations, written and oral exam.