Learning outcomes of the course unit
This course aims to provide the informations and the scientific backround to approach correctly the main topics of Clinical Biochemistry so as to figure out the complexity concerning the biological samples, the possible sources of error and the valuable amount of information therein. This knowledge is needed especially by a professionals working in clinics or surgery departments.
There are no obligatory prerequisites, but Clinical Biochemistry is an interdisciplinary science and needs the basic knowledge of Biology, Anatomy, Physiology, Chemistry and Biochemistry
Course contents summary
Typeof laboratory test: purposes and usefulness. Biological specimens: instruction for optimal collection, treatment and conservation (avoiding pre-analytical variation).
Analysis of biological samples; analytical techniques and instrumentations. Analytical and post-analytical variability affecting the laboratory data. Clinical laboratory quality assurance Kits for diagnostic tests. Current waived test. Implementation and monitoring of POCT.
Markers of function or damage of some organs and systems. Index of cytolysis, clinical enzymology. Main cardiac, hepatic, renal and tumor markers. Toxicology, therapeutic drug monitoring; Urine analysis. Laboratory tests in pregnancy. Maternal and fetal reference values
The analysis in the clinical laboratory. The biological sample: preparation of the subject, collection, processing and storage (pre-analytical variability).
Analysis of biological samples. Analytical and post-analytical variables that can affect the data. Criteria for non-acceptance of a biological sample. The quality control .. Laboratory tests decentralized.
Function and markers of injury to major organs and systems: index of cytolysis, clinical enzymology, function parameters, cardiac, hepatic and renal function. Analysis of urine. Laboratory tests in pregnancy maternal and fetal reference values.
G. Kellerman. Valori anormali di laboratorio. McGraw-Hill
Assessment methods and criteria
The material used for the preparation of educational activities (slides, text other than those of reference, different sources accessible over the network, etc.) is explained in the lectures and is available on request of the student.