IMMUNOLOGY AND IMMUNOPATHOLOGY
Learning outcomes of the course unit
Inflammatory processes and immune system are in troduced as basic response to injuries. Basis to comprehend the organization, function and regulatory mechanisms of body defences, so important to maintain body health, will be provided. Examples will demonstrate the essential importance of antigen recognition mechanisms for body protection. Basis for comprehension of immune system iperergic reactions, when regulatory mechanisms fail, will be provided. The principals autoimmunitary mechanisms will be presented.
Prerequisites
none
Course contents summary
Inflammatory processes and immune system are in troduced as basic response to injuries. Basis to comprehend the organization, function and regulatory mechanisms of body defences, so important to maintain body health, will be provided. Examples will demonstrate the essential importance of antigen recognition mechanisms for body protection. Basis for comprehension of immune system iperergic reactions, when regulatory mechanisms fail, will be provided. The principals autoimmunitary mechanisms will be presented.
Course contents
The immune system (cells, primary and secondary lynphoid organs), lymphocytes recirculation
Acute inflammation: definition, aetiology, vascular and cellular changes, inflammatory cells and chemokynes, resultsa and consequences.
Chronic inflammation, primary and granulomatous: cellular aspects and mediators, systemic effects
Innate and acquired immunity
Antigens: structure and functions. Antigen-antibody link. Monoclonal antibodies.
B lynphocytes receptor and T lymphocytes receptor: Lymphocytes repertoire formation and clonal selection.
MHC I and II classes: structure and functions. Oesogenous and endocgenous antigen processing. Antigen presenting cells and organs transplantation.
Lymphocytes activation. Primary and secondary response. Immunological memory.
Laboratory methods based on antigen-antibody reactions and adaptative immunity cells.
Immunopathology princeples: hypersensitivities (I, II, III, IV). Tolerance and autoimmunity and pathogenetic mechanisms. Immunodeficiecies and immunodepression. Stress and immune system.
Recommended readings
Veterinary Immunology, Tizard I.R., Elsevier 8°edizione(2011)
Pier G., Lyczak J.B., Wetzler L.M., Immunologia Infezione, Immunità, (2006) Piccin
Murphy K, Travers P., Walport M, Janeway's Immunobiologia, (2009) Saunders
McGavin M.D., Zachary J.F., Patologia Generale Veterinaria, (2008) Elsevier
Robbins e Cotran-le basi patologiche delle malattie vol 1 (2010) Elsevier
Teaching methods
theoretical lessona with slides presentation (42 ore)
Assessment methods and criteria
written exam: open questions (2 hours)
