IMMUNOLOGY AND IMMUNOPATHOLOGY
cod. 1004394

Academic year 2012/13
3° year of course - First semester
Professor
Academic discipline
Patologia generale e anatomia patologica veterinaria (VET/03)
Field
Attività formative affini o integrative
Type of training activity
Related/supplementary
42 hours
of face-to-face activities
6 credits
hub: PARMA
course unit
in - - -

Learning objectives

Inflammatory processes and immune system are in troduced as basic response to injuries. Basis to comprehend the organization, function and regulatory mechanisms of body defences, so important to maintain body health, will be provided. Examples will demonstrate the essential importance of antigen recognition mechanisms for body protection. Basis for comprehension of immune system iperergic reactions, when regulatory mechanisms fail, will be provided. The principals autoimmunitary mechanisms will be presented.

Prerequisites

none

Course unit content

Inflammatory processes and immune system are in troduced as basic response to injuries. Basis to comprehend the organization, function and regulatory mechanisms of body defences, so important to maintain body health, will be provided. Examples will demonstrate the essential importance of antigen recognition mechanisms for body protection. Basis for comprehension of immune system iperergic reactions, when regulatory mechanisms fail, will be provided. The principals autoimmunitary mechanisms will be presented.

Full programme

The immune system (cells, primary and secondary lynphoid organs), lymphocytes recirculation
Acute inflammation: definition, aetiology, vascular and cellular changes, inflammatory cells and chemokynes, resultsa and consequences.
Chronic inflammation, primary and granulomatous: cellular aspects and mediators, systemic effects
Innate and acquired immunity
Antigens: structure and functions. Antigen-antibody link. Monoclonal antibodies.
B lynphocytes receptor and T lymphocytes receptor: Lymphocytes repertoire formation and clonal selection.
MHC I and II classes: structure and functions. Oesogenous and endocgenous antigen processing. Antigen presenting cells and organs transplantation.
Lymphocytes activation. Primary and secondary response. Immunological memory.
Laboratory methods based on antigen-antibody reactions and adaptative immunity cells.
Immunopathology princeples: hypersensitivities (I, II, III, IV). Tolerance and autoimmunity and pathogenetic mechanisms. Immunodeficiecies and immunodepression. Stress and immune system.

Bibliography

Veterinary Immunology, Tizard I.R., Elsevier 8°edizione(2011)
Pier G., Lyczak J.B., Wetzler L.M., Immunologia Infezione, Immunità, (2006) Piccin

Murphy K, Travers P., Walport M, Janeway's Immunobiologia, (2009) Saunders

McGavin M.D., Zachary J.F., Patologia Generale Veterinaria, (2008) Elsevier

Robbins e Cotran-le basi patologiche delle malattie vol 1 (2010) Elsevier

Teaching methods

theoretical lessona with slides presentation (42 ore)

Assessment methods and criteria

written exam: open questions (2 hours)

Other information

- - -