General pharmacology. What is pharmacology. Drugs. Basic pharmacodynamics: sites and mechanisms of action, agonists and antagonists, partial agonists, the dose-effect relationship.
Basic pharmacokinetics: how drugs reach their site of action, routes of administration, drug adsorption. Drug-protein binding and drug biodistribution.
Drug biotransformation. Drug excretion. Pharmacokinetic parameters: bioavailability, apparent distribution volume, plasma drug half-life, clearance. Conditions modifying drug effects: drug interactions, the importance of patient conditions. Tolerance and resistance. Drug toxicity:
collateral and unwanted events.
Neuromuscular drugs: depolarizing and competitive blocking agents, botulinum, central (GABAergic) and preripheral myorelaxant agents. Drugs for myasthenia gravis: anticholinesterase drugs, steroids, immunosuppressant drugs.
Analgesic drugs: opiates and non-opiate analgesics; local anesthetics.
Antiinflammatory drugs: NSAIDs, non-selective COX inhibitors; COX-2 preferential and COX2-selective NSAIDs; steroids (glucocorticoids).
Antirheumatic drugs (DMARDs), antigout drugs (colchicine, allopurinol, uricosuric agents).
Drugs for Arthrosis: condroprotective drugs.